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30-Jun-2017 10:30

Indeed, several studies have reported an increased incidence of Herpes Zoster in patients with SLE [13–18].There have been no studies in the Saudi population addressing the frequency or natural history of Herpes Zoster infections in patients with SLE or the desirability of withdrawing their immunosuppressive medications and or instituting antiviral therapy.In this paper retrospective case controlled study was used to determine its frequency, assess specific risk factors, its association with SLE disease manifestations, and their treatment, and defines prognostic indicators for serious complications of Herpes Zoster.SLE patients defined by the ACR 1982 revised criteria seen at the outpatient and inpatient facilities of the university hospital that developed Herpes Zoster were considered for the period extending from 1982 to 2006.More cases than controls had lupus nephritis, cerebritis, thrombocytopenia but the differences did not reach statistical significance.The mean oral prednisolone dose and proportion of patients receiving immunosuppressives including pulse methylprednisolone therapy, IV Cyclophosphamide and mycophenolate was significantly higher in patients with active SLE compared to patients with SLE in remission at the time of Herpes Zoster ().Division of Rheumatology, Department of Medicine, College of Medicine, King Saud University, P. Box 2925, Riyadh 11461, Riyadh, Saudi Arabia Received 26 January 2010; Revised 1 June 2010; Accepted 19 August 2010Academic Editor: Francesco Indiveri Copyright © 2010 Afsar Sayeeda et al.

Patients with SLE may be at increased risk for Zoster infection by virtue of both the impairment in cell-mediated immunity which characterizes the disease and by treatment of severe disease with high dose corticosteroids or immunosuppressive agents.Patients with SLE carry an increased risk of infection that account for 11–23% of all hospitalized patients and 50% of all SLE patients develop major infections during the course of their disease.



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